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. Author manuscript; available in PMC: 2011 Nov 30.
Published in final edited form as: Cell Cycle. 2009 Sep 2;8(17):2769–2778. doi: 10.4161/cc.8.17.9410

Figure 1. Loss of WRN decreases survival of cells treated with Cr(VI).

Figure 1

Cell survival was determined by clonogenic assay. Results are means±SD of 2–3 independent experiments, each with triplicate dishes per dose. Where not seen, error bars were smaller than the symbol. Statistics (Student’s t-test): *- p<0.05, **- p<0.01 relative to WRN-deficient cells. (A) Clonogenic viability of WS and NF fibroblasts treated with Cr(VI). (B) WRN levels in NF (top panel) and LNS (lower panel) cells expressing targeting and nonspecific (GFP) shRNA. (C) Cr(VI) toxicity in NF cells expressing WRN-targeting or nonspecific (GFP) shRNA. (D) Survival of LNS cells expressing WRN or GFP-targeting shRNA.