Figure 9.

ADAM disintegrin loops. (Top) Disintegrin loop sequences of all known ADAM 2 and ADAM 3 orthologues are shown. (Bottom) Disintegrin loop sequences of all known functional ADAM disintegrin domains are shown. Circled residues have been shown to be critical. Residues surrounded with dotted circles have been shown or implicated to contribute to activity. Identical residues within groups are boxed. The position of the central cysteine is marked with an asterisk. Accession numbers for the sequences can be obtained at http://www.people.Virginia.EDU/∼jag6n/Table_of_the_ADAMs.html.