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. Author manuscript; available in PMC: 2012 Nov 22.
Published in final edited form as: J Am Coll Cardiol. 2011 Nov 22;58(22):2332–2339. doi: 10.1016/j.jacc.2011.07.048

Figure 5. A schematic figure of the relation between Ang II, c-Src and Cx43.

Figure 5

c-Src mediates the effect of Ang II on Cx43 reduction and impaired gap junction function. PP1 is a known specific inhibitor of c-Src tyrosine kinase that interrupts Ang II mediated Cx43 reduction, myocyte uncoupling and sudden arrhythmic death.