Fig. 5.
Concentration-dependent modification of the voltage dependence of steady-state inactivation of sodium channels in HEK-Nav1.6 cells by tefluthrin (A) and deltamethrin (B). Normalized amplitudes of peak sodium currents were plotted as a function of test potential and curves were drawn by fitting mean values to the Boltzmann equation. Data points in the shaded regions were omitted from the fits of data obtained in the presence of pyrethroids (see text for details). Values are the means of the indicated number of determinations with different cells; bars show SE values larger than the data point symbols. Dashed lines show the curve obtained by fitting mean control values to the Boltzmann equation (from Fig. 1B).