Table 2.
Effects of tefluthrin and deltamethrin on the kinetics of fast inactivation and tail current decay of sodium channels expressed in HEK-Nav1.6 cells.
| Peak Current Inactivationb | Tail Current Decayc | ||||
|---|---|---|---|---|---|
| Conditiona | τfast | τslow | n | τ1 | n |
| Control | 0.98 ± 0.02 | 5.26 ± 0.19 | 66 | -- | |
| + Tefluthrin | 1.32 ± 0.12 d | 31.87 ± 0.81 d | 12 | 40.3 ± 3.6 | 17 |
| + Deltamethrin | 1.35 ± 0.06 d | 8.65 ± 0.93 d | 9 | NDe | |
a
Pyrethroids assayed at 10 µM.
b
Time constants (ms) for the fast (τfast) and slow (τslow) components of sodium current inactivation; values are means ± SE for the indicated number of replicate experiments with different cells.
c
Time constant (ms) for the fast (τ1) component of tail current decay; values are means ± SE for the indicated number of replicate experiments with different cells.
d
Values were significantly different from control values.
e
Not determined.