Table 3.

Effects of tefluthrin and deltamethrin on the voltage dependence of activation and steady-state inactivation of sodium channels expressed in HEK-Na_v1.6 cells.^a

	Activation			Inactivationb
Condition	V0.5	K	n	V0.5	K	n
Control	−29.3 ± 0.6*c	5.08 ± 0.13*	72	−64.2 ± 0.5*	6.09 ± 0.09*	66
+ Tefluthrin
0.1 µM	−35.7 ± 1.1†	5.11 ± 0.21*	24	−70.3 ± 1.0†	6.77 ± 0.11†	22
1 µM	−39.3 ± 1.3†	6.30 ± 0.34†	26	−73.7 ± 1.0†	6.44 ± 0.14*	20
10 µM	−44.7 ± 1.9‡	6.61 ± 0.32†	19	−76.3 ± 1.0‡	6.25 ± 0.20*	16
100 µM	−48.5 ± 1.7‡	7.21 ± 0.34†	14	−79.3 ± 1.0‡	6.28 ± 0.25*	13
+ Deltamethrin
0.1 µM	−31.9 ± 1.2*†	5.31 ± 0.21*	17	−66.2 ± 1.3*†	6.25 ± 0.24*	14
1 µM	−34.2 ± 1.0†	5.25 ± 0.28*	15	−68.4 ± 1.1†§	6.42 ± 0.26*	15
10 µM	−36.0 ± 1.2†	5.88 ± 0.26*	16	−71.6 ± 1.5§	6.32 ± 0.37*	12

^aValues calculated from fits of the data from the indicated number of individual experiments to the Boltzmann equation; V_0.5, midpoint potential (mV) for voltage-dependent activation or inactivation; K, slope factor.

^bData for prepulse potentials from −55 mV to −25 mV were omitted from fits of inactivation data to the Boltzmann equation; see text for explanation.

^cValues in each column for control and concentrations of either tefluthrin or deltamethrin that are marked with the different symbols were significantly different.