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. Author manuscript; available in PMC: 2011 Dec 15.
Published in final edited form as: Biochem J. 2011 Dec 15;440(3):385–395. doi: 10.1042/BJ20102148

Figure 4. Adiponectin promotes PTP1B activity.

Figure 4

A) Analysis of PTP1B activity in liver tissue collected from livers of wild-type (WT) and Adiponectin knockout mice (Ad−/−). Administration of CCl4 (2 ml/kg) reduced PTP1B activity in both wild-type and Ad−/− mice. Leptin administration (5 mg/kg) further suppressed PTP1B activity. In both treatments, PTP1B activity was significantly less in Ad−/− mice than in wild-type mice. *p < 0.05 vs. WT B) In vitro analysis of PTP1B activity in rat HSCs treated for 30 min with leptin (Lep), adiponectin (Adi), both (LA), or neither. Adiponectin stimulated PTP1B activity whether administered alone or in the presence of leptin. *p < 0.05 vs. Untreated