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. Author manuscript; available in PMC: 2011 Dec 15.
Published in final edited form as: Biochem J. 2011 Dec 15;440(3):385–395. doi: 10.1042/BJ20102148

Figure 8. Adiponectin blocks leptin-stimulated formation of MMP-1/TIMP-1 complexes.

Figure 8

Data from ELISA of conditioned media from rat HSCs treated for 24h with leptin (Lep, 100ng/ml), adiponectin (Adi, 10μg/ml), both (LA), or neither demonstrated that leptin stimulated formation of MMP-2/TIMP-1 complexes (*p < 0.05 vs. untreated), while co-administration of adiponectin in the presence of leptin significantly reduced the formation of MMP-1/TIMP-1 complexes compared with leptin alone (#p < 0.05 vs. leptin).