Table 1.
Changes in heart rate, maximal rates of contractility (dP/dt max) and relaxation (dP/dt min), O2 consumption, % O2 extraction, and cardiac efficiency at baseline and 60 min reperfusion.
| Baseline | Reperfusion 60 min | |
|---|---|---|
| Heart Rate (beats/min) | ||
| Control | 276±9 | 269±6 |
| CP | 269±6 | 262±7 |
| CP+MCG | 269±15 | 279±8 |
| dP/dt max (mmHg/s) | ||
| Control | 2024±175 | 735±142 |
| CP | 1909±193 | 1221±141# |
| CP+MCG | 2012±168 | 1040±67# |
| dP/dt min (mmHg/s) | ||
| Control | −1502±124 | −516±101 |
| CP | −1542±206 | −904±112# |
| CP+MCG | −1577±171 | −716±54# |
| O2 consumption (μl O2/g/min) | ||
| Control | 105.1±7.8 | 57.6±6.8 |
| CP | 102.2±7.0 | 81.4±6.8# |
| CP+MCG | 121.8±8.7 | 87.3±5.6# |
| % O2 extraction | ||
| Control | 72±4 | 76±5 |
| CP | 76±2 | 85±2# |
| CP+MCG | 73±3 | 81±4 |
| Cardiac efficiency (mmHg • beat • 0.1 μL O2 / g) | ||
| Control | 23±3 | 14±2 |
| CP | 23±1 | 16±1 |
| CP+MCG | 18±1 | 14±2 |
Values are mean ± SEM
Abbreviations: CP, high K+ cardioplegia; CP+MCG, high K+ cardioplegia with MnTBAP, catalase, and glutathione.
#
P < 0.05 each treatment vs. the control group
¶
P < 0.05, CP+MCG vs. CP