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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Stroke. 2011 Sep 29;42(12):3606–3611. doi: 10.1161/STROKEAHA.111.628008

Figure 6. Oxytocin suppresses microglial reactivity in vitro.

Figure 6

(A) Microglial MHC class II expression is up-regulated following a 24 hour LPS challenge (1µg/mL). Pre-incubation with the high dose (1 µM) but not the low dose (0.1 µM) OT attenuates LPS-stimulated MHC class II expression, however this effect is blocked by co-incubation with OTA (1 µM), n = 7 per treatment condition. (B) MHC Class II expression was measured on total CD11b+ cells as gated above. Graph reflects fold change of LPS alone or LPS+OT stimulation. * indicates a statistically significant difference between indicated groups, (P > 0.05).