Table 1.
Demographic and Clinical Variables Across Quartiles of MPO (n=3294)
| Variable | Q1 (n=823) | Q2 (n=824) | Q3 (n=824) | Q4 (n=823) | P trend |
|---|---|---|---|---|---|
| MPO (ng/mL) | 3.7–13.34 | 13.35–17.12 | 17.13–21.58 | 21.59–183.33 | |
| Age (years) | 44 | 43 | 43 | 44 | 0.22 |
| Male | 43% | 46% | 43% | 44% | 0.77 |
| White | 35% | 32% | 28% | 23% | <0.001 |
| African American | 46% | 51% | 52% | 57% | <0.001 |
| Hispanic | 15% | 15% | 19% | 18% | 0.03 |
| Body Mass Index (kg/m2) | 28.1 | 29.3 | 29.6 | 30.8 | <0.001 |
| Hypertension | 32% | 35% | 31% | 37% | 0.14 |
| Current smoker | 27% | 27% | 29% | 34% | <0.001 |
| Hypercholesterolemia | 13% | 13% | 13% | 13% | 0.80 |
| Low HDL | 37% | 40% | 44% | 45% | <0.001 |
| High Triglyceride | 12% | 12% | 12% | 13% | 0.45 |
| Diabetes Mellitus | 9% | 12% | 12% | 14% | 0.001 |
| TNFR1A (ng/mL) | 0.38 | 0.55 | 0.67 | 0.94 | <0.001 |
| SP-B (ng/mL) | 1.13 | 2.21 | 2.99 | 6.52 | <0.001 |
| MCP-1 (pg/ml) | 29.8 | 34.9 | 37.9 | 42.6 | <0.001 |
| Osteoprotegerin (pg/ml) | 1168 | 1182 | 1202 | 1233 | 0.001 |
| MMP9 (ng/mL) | 3.3 | 4.8 | 6.0 | 10.1 | <0.001 |
| IL18 (mg/L) | 492.7 | 501.2 | 536.9 | 556.6 | 0.002 |
| hsCRP (mg/L) | 2.4 | 2.5 | 2.7 | 4.2 | <0.001 |
| SRAGE (ng/mL) | 1.4 | 1.9 | 2.1 | 2.3 | <0.001 |
Values are medians (interquartile range) for continuous variable and proportions for categorical variables. TNFR1A, tumor necrosis factor-alpha 1 receptor; SP-B, pulmonary surfactant protein-B; MCP-1, monocyte chemoattractant protein-1; MMP9, matrix metalloproteinase-9; IL18, interleukin-18; hsCRP, high sensitivity C-reactive protein; SRAGE, soluble receptor for advanced glycation end products.