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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Am J Transplant. 2011 Aug 29;11(12):2593–2602. doi: 10.1111/j.1600-6143.2011.03720.x

Figure 5. Gal-deficient islets induce less liver inflammation but similar xenoantibody levels as Gal-positive islets.

Figure 5

(a-b) WT islet recipients experienced a greater increase from baseline in the liver enzymes AST (c) and ALT (d); this difference was significant for AST on days 21 (p=0.03) and 28 (p=0.03) post-transplant. (e-f) All WT and GTKO islet recipients experienced a transient increase in anti-Gal IgM and a smaller increase in anti-Gal IgG antibodies, which peaked ~21 days post-transplant. There was no significant difference in antibody levels between groups at any timepoint. Alloislet recipients (n=4), shown for comparison, demonstrated a similar pattern of increase in anti-Gal IgM and IgG following transplant. P-values calculated using Mann-Whitney Test. *p <0.05; BG – blood glucose; POD – post-op day; AST – aspartate aminotransferase; ALT – alanine aminotransferase; ODU – optical density units.