Table 2.
Common haplotypes estimated for the F7 cluster and association with plasma FVIIag, FVIIc, FVIIc/FVIIag ratio, FVIIa, F 1+2, and FIXpep in NPHS-II and WH-II studies.
| NPHS-II | WH-II | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hap. | rs555212 | rs762635 | rs510317 | I/D323* | rs1475931 | rs6046 | rs3211719 | Freq. (%) |
FVIIag % (SE) |
FVIIc % (SE) |
FVIIc /FVIIag Ratio |
FVIIa (ng/mL) |
F 1+2 (μmol/L) |
FIXpep (pmol/L) |
Freq. (%) |
FVIIc % (SE) |
| H1 | A | A | G | A1 | T | G | A | 36.51 | 130 (0.76) | 110 (0.61) | 0.87 (0.01) | 2.43 (0.05) | 0.75 (0.01) | 220 (3.60) | 38.36 | 88 (0.47) |
| H2 | G | C | A | A1 | T | G | A | 20.79 | 139 (1.01)‡ | 116 (0.80)‡ | 0.86 (0.01) | 2.58 (0.07)† | 0.79 (0.02)† | 217 (4.60) | 18.71 | 95 (0.67)‡ |
| H3 | A | A | G | A1 | T | G | G | 11.45 | 132 (1.35) | 110 (1.08) | 0.86 (0.01) | 2.35 (0.09) | 0.81 (0.02) | 220 (6.40) | 13.11 | 90 (0.79)‡ |
| H4 | A | A | G | A1 | G | G | A | 9.41 | 130 (1.48) | 111 (1.19) | 0.89 (0.01) | 2.54 (0.10) | 0.78 (0.03) | 205 (7.02) | 10.18 | 90 (0.91)‡ |
| H5 | A | A | G | A2 | T | A | A | 8.51 | 109(1.56)‡ | 87 (1.25)‡ | 0.84 (0.01)‡ | 1.60 (0.10)‡ | 0.77 (0.03) | 195 (7.07)‡ | 8.11 | 66 (1.01)‡ |
| H6 | A | A | G | A1 | G | G | G | 7.14 | 128 (1.71) | 110 (1.36) | 0.88 (0.01) | 2.40 (0.11) | 0.81 (0.03) | 208 (7.93) | 7.67 | 92 (1.05)‡ |
Hap., Haplotypes;
*
A1-del, A2-ins; FVIIag, Factor VII antigen; FVIIc, Factor VII coagulant activity; FVIIa Factor VII activated; F 1+2, Factor 1+2; FIX, Factor IX activation peptide; Freq., frequency;
†
P<0.05;
‡
P<0.01.