Table 3.
Haplotype frequencies in CHD and non-CHD subjects and the association between F7 haplotypes and risk for CHD events in NPHS-II and WH-II studies
| Haplotype | Non-CHD % | CHD % | Adjusted modela HR (95% CI), P-value |
Adjusted model 1b HR (95% CI), P-value |
Adjusted model 2c HR (95% CI), P-value |
|---|---|---|---|---|---|
| NPHS-II | |||||
|
| |||||
| H1 | 36.6 | 35.9 | Ref. | Ref. | Ref. |
| H2 | 20.4 | 24.3 | 1.17 (0.94–1.46), 0.159 | 1.18 (0.94–1.47), 0.150 | 1.21 (0.97–1.52), 0.091 |
| H3 | 11.6 | 10.0 | 0.92 (0.68–1.25), 0.601 | 0.98 (0.73–1.33), 0.897 | 0.98 (0.73–1.33), 0.916 |
| H4 | 9.6 | 8.2 | 0.92 (0.66–1.27), 0.598 | 0.86 (0.62–1.20), 0.383 | 0.86 (0.61–1.19), 0.358 |
| H5 | 8.4 | 9.4 | 1.21 (0.89–1.64), 0.228 | 1.21 (0.89–1.65), 0.225 | 1.07 (0.78–1.47), 0.681 |
| H6 | 7.2 | 6.7 | 1.01 (0.71–1.43), 0.968 | 1.02 (0.71–1.45), 0.932 | 1.02 (0.71–1.45), 0.932 |
|
| |||||
| Non-carriers of H2 | 62.5 | 56.2 | Ref. | Ref. | Ref. |
| Carriers of H2 | 37.5 | 43.8 | 1.25 (1.06–1.48), 0.009 | 1.26 (1.06–1.49), 0.008 | 1.34 (1.12–1.59), 0.001 |
|
| |||||
| Non-carriers of H5 | 83.9 | 81.5 | Ref. | Ref. | Ref. |
| Carriers of H5 | 16.1 | 18.5 | 1.26 (1.01–1.56), 0.039 | 1.29 (1.01–1.56), 0.040 | 1.13 (0.89–1.44), 0.300 |
|
| |||||
| WH-II | |||||
|
| |||||
| H1 | 37.9 | 43.0 | Ref. | Ref. | Ref. |
|
| |||||
| H2 | 19.1 | 15.2 | 0.73 (0.58–0.91), 0.005 | 0.72 (0.56–0.92), 0.007 | 0.73 (0.57–0.94), 0.016 |
|
| |||||
| H3 | 13.2 | 12.4 | 0.85 (0.66–1.08), 0.180 | 0.84 (0.65–1.09), 0.191 | 0.89 (0.68–1.16), 0.392 |
|
| |||||
| H4 | 10.2 | 10.4 | 0.94 (0.73–1.23), 0.664 | 0.98 (0.75–1.29), 0.901 | 1.05 (0.79–1.38), 0.749 |
|
| |||||
| H5 | 8.1 | 8.2 | 0.95 (0.71–1.26), 0.704 | 0.95 (0.70–1.29), 0.766 | 0.87 (0.62–1.20), 0.387 |
|
| |||||
| H6 | 7.7 | 7.3 | 0.85 (0.63–1.15), 0.299 | 0.84 (0.60–1.17), 0.299 | 0.84 (0.60–1.19), 0.337 |
|
| |||||
| Non-carriers of H2 | 65.5 | 71.4 | Ref. | Ref. | Ref. |
|
| |||||
| Carriers of H2 | 34.5 | 28.7 | 0.77 (0.65–0.91), 0.003 | 0.75 (0.63–0.90), 0.002 | 0.77 (0.64–0.93), 0.008 |
|
| |||||
| Non-carriers of H5 | 84.8 | 84.4 | Ref. | Ref. | Ref. |
|
| |||||
| Carriers of H5 | 15.2 | 15.6 | 1.08 (0.88–1.33), 0.466 | 1.07 (0.86–1.34), 0.523 | 0.95 (0.74–1.22), 0.675 |
*
Percentages across the haplotype; HR, hazard ratio; OR, odds ratio (for WH-II); CI, confidence interval 95%; Ref., reference.
a
adjusted for age, clinic (only NPHS-II).
b
adjusted for age, clinic (only NPHS-II), BMI, diabetes, total cholesterol, smoking, and systolic blood pressure.
c
adjusted for age, clinic (only NPHS-II), BMI, diabetes, total cholesterol, smoking, systolic blood pressure, and FVIIc.