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Effect of doxercalciferol on biochemical markers of cardiac hypertrophy and cardiac dysfucntion. (A) Serum BNP level was significantly attenuated in doxercalciferol treated group than in vehicle treated group. (B) LV tissue ANF mRNA level was also reduced with doxercalciferol treatment. Serum BNP and tissue ANF levels were determined using ELISA and qRT-PCR, respectively. ND=normal diet, HS=high salt diet, V=vehicle, D=doxercalciferol. *p<0.05, N=6–9.
