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. 2011 Dec;138(6):581–592. doi: 10.1085/jgp.201110683

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© 2011 Trudeau et al.

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Figure 2. — hERG1a NTR polypeptides regulate steady-state properties of hERG1a/hERG1b channels. Whole cell patch-clamp recordings of (A) hERG1a, (B) hERG1a/hERG1b channels, (C) hERG1a/hERG1b plus hERG1a 1–181, (D) hERG1a/hERG1b plus hERG1a 1–228, (E) hERG1a/hERG1b plus hERG1a 1–319, and (F) hERG1a/hERG1b plus hERG1a 1–365. The voltage protocol (shown at the bottom) consisted of steps from −100 to 60 mV for 2-s durations in 20-mV increments, followed by a step to −50 mV for 2 s. The holding potential was −80 mV. (G) Plot of I-V relationship for each channel in A–F normalized to peak tail current at −50 mV. (H) G-V relationship for channels in A–F. Bars in A–F, 0.5 s; n ≥ 6.