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. 2011 Dec;138(6):581–592. doi: 10.1085/jgp.201110683

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© 2011 Trudeau et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 4. — hERG1a/hERG1b currents generated by an action potential voltage clamp were reduced by hERG1a NTR polypeptides. (A) Currents elicited using an action potential voltage clamp (as indicated) from hERG1a, hERG1a/hERG1b, and hERG1a/hERG1b plus 1–365, as labeled. n ≥ 3 for each. For comparison, currents were normalized to the peak tail current at −50 mV after a pulse to 60 mV. Vertical scale bar is normalized units, and horizontal scale bar is time (0.1 s). (B) Box plot of magnitude of peak current. (C) Box plot of time after the onset of the voltage pulse at which peak current occurred (*, P < 0.05; ANOVA).