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. 2011 Dec;138(6):627–640. doi: 10.1085/jgp.201110693

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© 2011 Su et al.

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Figure 8. — A homology model of the S5–S6 core domain of the TRPY1 channel to visualize the nature of the in-plane expansion upon opening. The computational model was constructed using the ROSETTA algorithm (Simons et al., 1997) based on limited homology between TRPY1 and K⁺ channels (see supplemental information in Zhou et al., 2007). For clarity, only residues from 363 to 472 are shown as ribbons. Upon opening, both the external S5 helices (yellow) and the pore-lining S6 helices (blue) are modeled to bend, tilt, and expand driven by membrane tension.