Table 1.
Reaction list. (Italics denote clamped metabolites; bold type indicates lipid species. The variable species are PC, PE, phosphatidylserine (PS), phosphatidic acid (PA), 1,2-diacyl-sn-glycerol (DAG), lysoPC (LPC), lysophosphatidylethanolamine (LPE), lysoPS (LPS), fatty acid (FA), acyl coenzyme A (AcCoA), CDP-choline (CDPcho), CDP-ethanolamine (CDPeth), CDP-diacylglycerol (CDP-DAG), phosphatidylinositol (PI), phosphatidylinositol 4-phosphate (PIP), phosphatidylinositol 4,5-biphosphate (PIP2), sphingomyelin (SM), ceramide (Cer), N-acetylsphinganine (NacSa), sphinganine (Sa), sphinganine 1-phosphate (Psa), sphingosine 1-phosphate (Pso), sphingosine (So).)
| rxn | stoichiometry | rxn | stoichiometry |
|---|---|---|---|
| R1 | cho+ATP=pcho+ADP | R28 | LPA+AcCoA=CoA+PA |
| R2 | eth+ATP=peth+ADP | R29 | LPC+AcCoA=CoA+PC |
| R3 | pcho+H2O=cho+Pi | R30 | LPS+AcCoA=CoA+PS |
| R4 | peth+H2O=eth+Pi | R31 | LPE+AcCoA=CoA+PE |
| R5 | pcho+CTP=Ppi+CDPcho | R32 | H2O+LPC=cho+LPA |
| R6 | peth+CTP=Ppi+CDPeth | R33 | H2O+LPS=serine+LPA |
| R7 | gly3pho+AcCoA=CoA+LPA | R34 | H2O+LPE=eth+LPA |
| R8 | FApre=FA | R35 | CoA+FA=H2O+AcCoA |
| R9 | CDPcho+DAG=CMP+PC | R36 | CTP+PA=Ppi+CDPDAG |
| R10 | CDPeth+DAG=CMP+PE | R37 | inos+CDPDAG=CMP+PI |
| R11 | PC+cer=DAG+SM | R38 | ATP+PI=ADP+PIP |
| R12 | H2O+PC=pcho+DAG | R39 | ATP+PIP=ADP+PIP2 |
| R13 | H2O+PA=Pi+DAG | R40 | H2O+PIP2=inosP3+DAG |
| R14 | H2O+PS=pcho+DAG | R41 | SM=pcho+cer |
| R15 | H2O+PE=peth+DAG | R42 | serine+AcCoA=CoA+Sa |
| R16 | ATP+DAG=ADP+PA | R43 | Sa=Psa |
| R17 | H2O+PC=cho+PA | R44 | AcCoA+Sa=CoA+NAcSa |
| R18 | H2O+PS=cho+PA | R45 | NAcSa=cer |
| R19 | H2O+PE=eth+PA | R46 | cer=FA+So |
| R20 | PS=CO2+PE | R47 | So=Pso |
| R21 | eth+PS=serine+PE | R48 | Pso=peth+FA |
| R22 | serine+PC=cho+PS | R49 | Psa=peth+FA |
| R23 | serine+PE=eth+PS | R50 | CDPcho→SINK |
| R24 | H2O+PA=LPA+FA | R51 | CDPeth→SINK |
| R25 | H2O+PC=LPC+FA | R52 | PC→SINK |
| R26 | H2O+PS=LPS+FA | R53- | X→SINK |
| R27 | H2O+PE=LPE+FA | −73 |