Figure 1. Comparison of mRNA expression levels for classical activation, alternative activation and acquired deactivation genes associated with the brain's innate immune response between a mouse model of amyloid deposition and a model of disease progression.

Results represent the means±S.E.M. fold-change in mRNA levels for classical activation genes (A) and for alternative activation genes and acquired deactivation genes (B) in 52–60-week-old NOS2^−/−, APPSw and APPSw/NOS2^−/− mice brain samples compared with WT control mice of the same age (n = 5–7 mice per strain). *P<0.05, **P<0.01, ***P<0.001 compared with the NOS2^−/− control mice in each case. ^#P<0.05, ^##P<0.01, ^###</emph>P<0.001 compared with the parent strain.