Figure 6. Active immunization alters the immune profile in APPSw/NOS2^−/− mice.

Mice were immunized with either Aβ-(1–42) or KLH at 12 months of age as described in the Materials and methods section and compared with age-matched NOS2^−/− mice immunized in a similar fashion. (A, B) Results represent the means±S.E.M. fold-change in mRNA levels for selected classical activation genes (A) and for selected alternative activation and acquired deactivation genes (B) in APPSw/NOS2^−/− mice. (C) mRNA for alternative activation genes (Mrc1; CD163) associated with the cerebrovasculature (n = 5–7 mice/group in all cases). **P<0.01, ***P<0.001 compared with control mice. ^#P<0.05, ^##P<0.01 compared with the Aβ42 immunized condition in each case.