Table 2. Summary of previously published data for mouse pathology and anti-Aβ immunotherapy studies.

Numbers in brackets are the number of mice. *P<0.05 compared with APPSw; CAA, cerebral amyloid angiopathy (vascular amyloid); RAWM, radial arm water maze.

			Histopathological data
Study	Mouse model	Age (months)	Total Aβ (pg/ml)	CAA	p-tau soma	Neuron loss	Cognition	References
Non-treated	APPSw	12–16	662±100 (5)	+	None	None	Decrease Y maze; increase latency to platform (Morris water maze); no change from NOS2−/− (RAWM)	(Hsiao et al., 1996; Colton et al., 2006b; Wilcock et al., 2008, 2009)
Non-treated	APPSw/NOS2−/−	12–16	3172±1072* (3)	+++	++	Down ∼30%	Decrease (RAWM)	(Colton et al., 2006b; Wilcock and Colton, 2008; Wilcock et al., 2009)
Passive immunization	APPSw	19–22	Decrease 60%	Increase 4-fold	n/a	n/a	Improved	(Wilcock et al., 2004a; 2004b)
Active vaccination	APPSw/NOS2−/−	12–16	Decrease 85%	No change	Down 50–60%	No further loss	Reversed	(Wilcock et al., 2009)