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. 2011 Dec;21(12):2049–2057. doi: 10.1101/gr.122721.111

Figure 4.

Figure 4.

Estimation of the proportion of germline-methylated SUMIs. To estimate the proportion of germline-methylated SUMIs in the 761 SUMIs that are methylated in human, chimp, and orang neutrophils, we calculated CG decay rates in 500 random subsets of these SUMIs. The observed distribution of decay rates of the subsets is shown by the blue circles. Simulated distributions calculated for different proportions of methylated SUMIs are shown by the dotted lines. The variance of the distribution is a measure of the proportion of methylated and unmethylated SUMIs in the 761 SUMIs: A small variance indicates that most of the SUMIs are methylated (curve for M = 90%); a large variance indicates that most of the SUMIs are unmethylated (curve for M = 20%). The value of M that gives the best visual fit to the distribution of observed rates is between 60% and 70%.

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