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. Author manuscript; available in PMC: 2011 Nov 30.
Published in final edited form as: Circ Res. 2007 May 24;100(12):1732–1740. doi: 10.1161/CIRCRESAHA.107.148791

Figure 2.

Figure 2

Enhanced cardiac repair and functions in mIGF-1 transgenic mice after myocardial infarction. A, Whole mount and histological analysis of sham-operated control (WT) heart (left) and LCA WT and TG hearts (right) 2 months after operation. Arrows indicate fibrotic tissue. LA indicates left atrium; LV, left ventricle; RA, right atrium; RV, right ventricle. Histological analysis by trichrome staining is shown for each treatment. B, Functional recovery of mIGF-1 transgenic mice after LCA. Mean percentage values of FS (upper panel) and EF (lower panel) are representative of 3 readings on each animal and averaged among groups. Asterisks (*) show significant values (P<0.05) between uninjured and injured hearts in WT (yellow square) and TG (red square) mice. § shows significant values between WT and TG injured hearts. C, Histological analysis (trichrome) of WT and TG hearts at 48 hours, 1 week, and 1 month after CTX injection in the left ventricular wall. Comparable results were obtained with similar analyses on 6 different groups. D, Functional recovery of mIGF-1 transgenic mice 1 month after CTX injection. Mean percentage values are representative of 3 readings on each animal and averaged among groups. Asterisk (*) indicates significant values decreasing in WT compared with TG hearts (P<0.05). E, Real time PCR of mIGF-1 transcript in physiological conditions and 24 hours after CTX injection, using IGF-1Ea Taqman probe (Applied Biosystem). PCR values were normalized for GAPDH content in each sample. Asterisk (*) indicates significant increasing values compared with WT uninjured hearts, whereas § represents significant decreasing values compared with TG uninjured hearts.