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. Author manuscript; available in PMC: 2011 Nov 30.
Published in final edited form as: J Bioanal Biomed. 2011 Jan 10;3:001–0007. doi: 10.4172/1948-593X.1000036

Figure 6.

Figure 6

Schematic illustration of the COX-2 dependent and independent mechanisms involved in mediating the synergistic antiproliferative effects of combined γ-tocotrienol and celecoxib treatment. The COX-2-dependent mechanism involve a suppression in COX-2 and PGE2 levels and a corresponding increase in PGDH levels, while the COX-2-independent mechanisms involve a reduction in the levels and EGF-dependent activation ErbB2-4 receptor levels and subsequent reductions in downstream Akt and NFκB mitogenic signaling.