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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Curr Opin Virol. 2011 Nov 1;1(5):339–346. doi: 10.1016/j.coviro.2011.09.005

Figure 4.

Figure 4

Model showing non-templated functions of the 5’ CL and the 3’ terminal sequence of the negative-strand RNA during initiation of positive-strand synthesis. The model suggests that partial unwinding of the duplex RF RNA allows the cellular protein, hnRNPC, and VPgpUpU to bind at the 3’ end of the negative-strand RNA [69]. This would also facilitate the formation of the 5’CL-RNP complex in positive-strand RNA as shown in the model. It is proposed that the 5’CL-RNP complex functions in trans to promote the VPgpUpU primed initiation of positive-strand synthesis by 3Dpol [72]. Although not shown, it is possible that hnRNPC bound to the 5’ end of the negative-strand RNA may also be part of the positive-strand initiation complex [71].