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Total time spent immobile in in the forced swim tests by C57BL/6J male mice treated with (A) 3-bromocytisine, (B) CP-601927 and (C) CP-601932 at several concentrations. Saline is used as the negative control group. (D) Treatment with fluoxetine at 10 mg/kg (Flx 10) and varenicline at 1.5 mg.kg (Varen 1.5; NOTE: these data were previously published in (Rollema et al., 2009). Error bars represent SEM.** P< 0.01, *** P< 0.001. N=10 for each treatment group.
