FIG. 3.—

Dosage effects of CNVs on expression in homozygotes. (A) In the left column, dosage sensitive indicates that CNVs have either copy-number increases with higher expression levels than reference strain PS1 or else that copy-number decreases with lower expression levels than PS1. In the right column, dosage reversed suggests opposite negative associations. The middle panel shows the number of CNVs that are not sensitive to copy-number dosage effects. (B) The bars indicate the fractions of dosage-sensitive (gray), dosage-insensitive (black) and dosage-reversed CNVs (white) for copy-number increases and decreases separately.