Table 1.
Vertebrate CEL, human and mouse carboxylesterase (CES1–5) and nematode CES genes and subunits.
| Vertebrate | Species | Gene CEL | RefSeq ID Prediction1,2 | GenBank ID | Chromosome location | Exons (strand) | Gene size (bps) | UNIPROT ID | Amino acids | Subunit MW | pI | No. of repeats |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | Homo Sapiens | CEL | NM_001807 | BC042510 | 9:134, 927, 202-134, 936, 969 | 11 (+ve) | 9,768 | P19835 | 756 | 79,667 | 5.1 | 17 |
| Gorilla | Gorilla gorilla | CEL | sc465912 | ³ | sc65914:90, 194-97, 985 | ³ | 7,791 | Q9N1D1 | 998 | 101,026 | 4.5 | 39 |
| Rhesus | Macaca mulatta | CEL | chr15.6.020² | ³ | 15:5, 562, 165-5, 571, 662 | 11 (−ve) | 9,498 | ³ | 731 | 78,302 | 4.8 | 15 |
| Mouse | Mus musculus | CEL | NM_009885 | BC006872 | 2:28, 411, 584-28, 418, 882 | 11 (−ve) | 7,543 | Q64285 | 598 | 65,666 | 5.9 | 3 |
| Rat | Rattus norvegicus | CEL | NM_016997 | M15893 | 3:7, 541, 329-7, 549, 228 | 11 (−ve) | 7,900 | P07882 | 612 | 67,052 | 5.3 | 4 |
| Guinea pig | Cavia porcellus | CEL | sc427.013.12 | ³ | sc274:846, 072-851, 868 | 11 (−ve) | 5,797 | ³ | 598 | 65,174 | 5.4 | 3 |
| Cow | Bos taurus | CEL | NP_001013601 | BC149530 | 11:106, 810, 242-106, 819, 101 | 11 (+ve) | 8,762 | P30122 | 599 | 65,598 | 5.2 | 3 |
| Horse | Equus caballus | CEL | chr25.415.1² | ³ | 25:35, 342, 417-35, 350, 330 | 11 (+ve) | 7,914 | ³ | 599 | 65,310 | 5.3 | 3 |
| Dog | Canis familiaris | CEL | chr9.55.011² | ³ | 9:54, 678, 403-54, 686, 294 | 11 (−ve) | 7,892 | ³ | 709 | 75,920 | 5.4 | 13 |
| Opossum | Monodelphis domestica | CEL | chr1.10.178² | ³ | 1:460, 155, 249-460, 171, 513 | 11 (+ve) | 16,265 | ³ | 579 | 63,553 | 6.4 | 1 |
| Platypus | Ornithorhynchus anatinus | CEL | ENSOANT23206² | ³ | Ultra814:471, 532-485, 254 | 11 (+ve) | 13,723 | ³ | 557 | 61,672 | 7.1 | 0 |
| Chicken | Gallus gallus | CEL | NP_001013015¹ | BX950478 | 17:7, 428, 231-7, 433, 490 | 11 (+ve) | 5,260 | ³ | 556 | 61,191 | 6.6 | 0 |
| Lizard | Anolis carolinensis | CEL | ENSACAT4924² | ³ | 3534:801, 542-811, 604 | 11 (+ve) | 10,063 | ³ | 553 | 61,438 | 6.1 | 0 |
| Frog | Xenopus tropicalis | CEL | NP_001120027¹ | ³ | 1914:155, 996-171, 454 | 11 (−ve) | 15,459 | ³ | 552 | 60,653 | 6.2 | 0 |
| Zebrafish | Danio rerio | CEL1 | NM_199607 | BC079529 | 21:4, 281, 250-4, 291, 233 | 11 (−ve) | 9,984 | ³ | 550 | 60,521 | 6.0 | 0 |
| Zebrafish | Danio rerio | CEL2 | AAH65887⁵ | BC096893 | 21:4, 298, 674-4, 307, 810 | 11 (−ve) | 9,137 | ³ | 550 | 60,425 | 6.1 | 0 |
| Stickleback | Gasterosteus aculeatus | CEL | ENSGACT24004² | ³ | XIV:11, 357, 393-11, 361, 602 | 11 (−ve) | 4,210 | ³ | 555 | 60,963 | 5.7 | 0 |
| Medaka | Oryzias latipes | CEL | ENSORLT18090² | ³ | 12:26, 977, 209-26, 983, 642 | 11 (+ve) | 6,434 | ³ | 552 | 60,329 | 5.8 | 0 |
| Fugu | Takifugu rubripes | CEL | ENSTRUG2423² | ³ | sc3704:307, 466, 106-307, 469, 087 | 11 (−ve) | 2,982 | ³ | 554 | 61,498 | 6.7 | 0 |
| Pufferfish | Tetraodon nigroviridis | CEL | CAF94246 | CR654166 | Un5:12, 727, 719-12, 730, 519 | 11 (−ve) | 4,210 | ³ | 555 | 60,859 | 5.7 | 0 |
| CES | ||||||||||||
| Human | Homo Sapiens | CES1 | NM_001025195 | L07765 | 16:54, 394, 465-54, 424, 468 | 14 (−ve) | 30,004 | P23141 | 567 | 62,521 | 6.2 | ³ |
| Mouse | Mus musculus | CES1a | NM_001013764 | BC089371 | 8:95, 544, 116-95, 572, 091 | 14 (−ve) | 27,979 | Q5FWH4 | 563 | 61,744 | 5.1 | ³ |
| Human | Homo Sapiens | CES2 | NM_003869 | BC032095 | 16:65, 527, 040-65, 535, 426 | 12 (+ve) | 8,387 | O00748 | 559 | 61,807 | 5.7 | ³ |
| Mouse | Mus musculus | Ces2a | NM_133960 | BC024491 | 8:107, 257, 972-107, 265, 313 | 12 (+ve) | 7,342 | Q8QZR3 | 558 | 61,940 | 5.7 | ³ |
| Human | Homo Sapiens | CES3 | NM_024922 | BC053670 | 16:65, 552, 712-65, 564, 450 | 13 (+ve) | 11,739 | Q9H6X7 | 571 | 62,282 | 5.4 | ³ |
| Mouse | Mus musculus | Ces3a | NM_198672 | AK138932 | 8:107, 572, 572-107, 582, 000 | 13 (+ve) | 21,512 | Q63880 | 554 | 61,510 | 5.8 | ³ |
| Human | Homo Sapiens | CES4A | NM_173815 | BC166638 | 16:65, 580, 177-65, 600, 543 | 14 (+ve) | 20,367 | Q5XG92 | 561 | 60,366 | 9.4 | ³ |
| Mouse | Mus musculus | Ces4a | NM_146213 | BC026374 | 8:107, 655, 852-107, 673, 417 | 14 (+ve) | 17,566 | ³ | 563 | 62,123 | 8.8 | ³ |
| Human | Homo Sapiens | CES5A | NM_001143685 | BC039073 | 16:54, 437, 867-54, 466, 634 | 13 (−ve) | 27,768 | Q6NT32 | 575 | 63,936 | 6.0 | ³ |
| Mouse | Mus musculus | Ces5a | NM_001003951 | AB186393 | 8:96, 038, 095-96, 059, 607 | 13 (+ve) | 21,512 | Q8R0W5 | 575 | 64,167 | 5.5 | ³ |
| Nematode | Caenorhabditis elegans | T28C12 | NM_072212 | AAB66159 | V:6, 323, 188-6, 326, 373 | 9 (+ve) | 3,186 | Q4LDP0 | 658 | 74,736 | 9.2 | ³ |
RefSeq refers to the NCBI reference sequence; ¹predicted NCBI sequence; ²predicted UCSC Genome Browser sequence; ³not available; 4gene scaffold ID; 5unidentified chromosome; pI refers to isoelectric point; bps refers to base pairs of nucleotide sequence; repeats number refers to the number of VNTR sequences at the CEL C-terminus.