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Identification of small molecule inhibitors using the Mero-S100A4. (A) Hit compounds identified in a screen of a library of FDA-approved drugs. Compounds that inhibited the Ca2+-induced fluorescence increase of the Mero-S100A4 to a similar extent as EGTA were considered to be hits. (B) IC50 values for inhibition of the Ca2+-induced fluorescence increase of the bio-sensor. The data represents the best fit to a three parameter logistic equation from two independent experiments.
