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. 2010 Jul 9;87(6):2209–2226. doi: 10.1007/s00253-010-2741-x

Table 4.

Genes with a significant induction at the transcript level in the solventogenesis

ORF# Gene Protein functiona 1. array 2. array 3. array 4. array Average fold reg. SD COGb
CAC0186 Xre family DNA-binding domain and TPR-repeat-containing protein 0.19 0.15 0.24 0.19 0.19 0.04 –
CAC0254 nifHD Nitrogen regulatory protein PII (nitrogen fixation nifHD) 0.21 0.17 0.53 0.43 0.33 0.17 E
CAC0255 nifHD Nitrogen regulatory protein PII (nitrogen fixation nifHD) 0.22 0.20 0.41 0.46 0.32 0.13 E
CAC0256 nifD Nitrogenase molybdenum–iron protein, alpha chain (nitrogenase component I) 0.21 0.16 0.42 0.47 0.32 0.15 C
CAC0392 Peptidoglycan-binding domain 0.30 0.28 0.25 0.36 0.30 0.04 M
CAC0538 ChW repeat-containing mannanase ManB 0.35 0.34 0.24 0.22 0.29 0.07 G
CAC0561 Cellulase CelE-like protein 0.04 0.05 0.11 0.07 0.07 0.03 –
CAC0574 Pectate lyase H (FS) 0.08 0.08 0.19 0.14 0.12 0.05 –
CAC0717 Predicted membrane protein 0.10 0.12 0.15 0.10 0.12 0.02 –
CAC0746 Secreted protease metal-dependent protease 0.14 0.15 0.27 0.25 0.20 0.07 S
CAC0826 Endoglucanase family 5 0.16 0.16 0.29 0.19 0.20 0.06 G
CAC0910 Cellulosomal scaffolding protein 0.007 0.007 0.012 0.007 0.008 0.003 G
CAC0911 Processive endoglucanase 0.007 0.007 0.012 0.010 0.009 0.002 –
CAC0912 Nonprocessive endoglucanase 0.007 0.006 0.013 0.007 0.008 0.003 G
CAC0913 Nonprocessive endoglucanase 0.010 0.008 0.012 0.008 0.009 0.002 –
CAC0914 Cellulosome integrating cohesin-containing protein, secreted 0.009 0.008 0.009 – 0.008 – –
CAC0915 Endoglucanase A 0.015 0.016 0.010 0.008 0.012 0.004 –
CAC0918 Nonprocessive endoglucanase 0.009 0.007 0.008 0.006 0.008 0.001 –
CAC0919 Sialidase 0.009 0.013 0.013 0.013 0.012 0.002 –
CAC1214 Xre family DNA-binding domain and TPR-repeat-containing protein 0.30 0.25 0.38 0.36 0.32 0.06 –
CAC1314 Hypothetical protein 0.03 0.03 0.04 0.04 0.03 0.002 –
CAC1315 Peptidoglycan-binding domain-containing protein 0.03 0.03 0.04 0.03 0.03 0.004 M
CAC1322 glpA Glycerol-3-phosphate dehydrogenase 0.06 0.09 0.15 0.08 0.09 0.04 R
CAC1323 NAD(FAD)-dependent dehydrogenase 0.13 0.16 0.29 0.19 0.19 0.07 O
CAC1324 Hypothetical protein 0.13 0.15 0.14 0.19 0.15 0.03 S
CAC1554 Heavy metal-binding domain-containing protein 0.32 0.34 0.30 0.24 0.30 0.05 S
CAC1611 Cation efflux pump (multidrug resistance protein) 0.34 0.33 0.27 0.26 0.30 0.04 V
CAC1673 gltA Large subunit of NADH-dependent glutamate synthase 0.22 0.26 0.36 0.43 0.32 0.09 E
CAC1968 Pectate lyase related enzyme 0.12 0.11 0.14 0.20 0.14 0.04 –
CAC1977 Predicted membrane protein 0.16 0.19 0.18 0.17 0.02 –
CAC1980 Predicted ATPase involved in pili biogenesis 0.25 0.26 0.28 0.28 0.27 0.01 U
CAC2052 DNA-dependent RNA polymerase sigma subunit 0.24 0.19 0.47 – 0.30 0.15 K
CAC2053 Hypothetical protein 0.27 0.19 0.43 0.26 0.29 0.10 –
CAC2293 Hypothetical protein 0.11 0.19 0.21 0.28 0.20 0.07 –
CAC2392 ABC transporter, ATPase component 0.18 0.19 0.34 0.22 0.23 0.07 V
CAC2393 ABC transporter, ATPase component 0.21 0.18 0.40 0.18 0.24 0.10 V
CAC2396 Xylanase/chitin deacetylase 0.25 0.29 0.29 0.21 0.26 0.04 G
CAC2404 Glycosyltransferase 0.21 0.17 0.20 0.13 0.18 0.03 R
CAC2405 Glycosyltransferase 0.18 0.14 0.28 0.14 0.19 0.07 M
CAC2406 O-antigen transporter permease 0.12 0.16 0.20 0.15 0.16 0.03 R
CAC2407 CheY-like domain-containing protein 0.18 0.15 0.20 0.14 0.17 0.03 T
CAC2408 Glycosyltransferase 0.14 0.12 0.24 0.18 0.17 0.05 M
CAC2450 Desulfoferrodoxin 0.28 0.35 0.27 0.21 0.28 0.06 C
CAC2497 Hypothetical protein 0.17 0.28 0.19 0.22 0.21 0.05 –
CAC2517 nrpE Extracellular neutral metalloprotease. NPRE 0.06 0.06 0.06 0.04 0.05 0.01 E
CAC2606 Hypothetical protein 0.18 0.19 0.37 0.36 0.28 0.10 G
CAC2607 Gluconate 5-dehydrogenase 0.20 0.19 0.52 0.28 0.30 0.15 I,Q,R
CAC2650 pyrD Dihydroorotate dehydrogenase 0.15 0.14 0.53 0.38 0.30 0.19 F
CAC2651 pyrZ Dihydroorotate dehydrogenase electron transfer subunit 0.15 0.13 0.56 0.32 0.29 0.20 H,C
CAC2652 pyrF Orotidine 5′-phosphate decarboxylase 0.16 0.12 0.63 0.30 0.30 0.23 F
CAC2653 pyrI Aspartate carbamoyltransferase regulatory subunit 0.21 0.21 0.44 0.33 0.30 0.11 F
CAC2654 pyrB Aspartate carbamoyltransferase catalytic subunit 0.15 0.12 0.34 0.34 0.24 0.12 F
CAC2920 tenI Thiamine monophosphate synthase 0.18 0.16 0.52 0.36 0.31 0.17 H
CAC2921 thiH Thiamine biosynthesis protein ThiH 0.15 0.13 0.56 0.33 0.29 0.20 H,R
CAC2922 thiG Thiazole synthase 0.15 0.14 0.39 0.24 0.23 0.11 H
CAC2923 Thiamine biosynthesis protein ThiF 0.15 0.14 0.37 0.24 0.23 0.11 H
CAC2924 thiS Hypothetical protein 0.15 0.15 0.35 0.21 0.22 0.10 H
CAC2928 Predicted membrane protein 0.22 0.15 0.10 0.06 0.13 0.07 S
CAC3166 Predicted DNA-binding protein 0.32 0.27 0.37 – 0.32 0.05 R
CAC3167 Hypothetical protein 0.26 0.20 0.44 0.24 0.29 0.11 S
CAC3276 nrdF Ribonucleotide-diphosphate reductase beta-subunit 0.38 0.49 0.17 0.14 0.30 0.17 F
CAC3279 ChW repeat-containing protein 0.26 0.28 0.33 0.20 0.27 0.05 N
CAC3280 ChW repeat-containing protein 0.33 0.30 0.34 0.21 0.29 0.06 N
CAC3387 Pectate lyase 0.16 0.17 0.06 0.07 0.11 0.06 –
CAC3469 Endoglucanase family protein 0.05 0.04 0.10 0.06 0.06 0.03 G
CAC3526 FMN-binding protein 0.30 0.22 0.40 0.37 0.32 0.08 –
CAC3612 Hypothetical protein 0.27 0.23 0.22 0.26 0.25 0.03 –
CAC3684 Polygalacturonase 0.21 0.20 0.42 0.27 0.27 0.10 M
CAC3693 Hypothetical protein 0.30 0.41 0.24 0.31 0.31 0.07 –
CAC3694 TPR-repeat-containing protein 0.32 0.37 0.30 0.31 0.32 0.03 R
CAC3695 Transcriptional regulator, containing DNA-binding domain of xre family 0.27 0.30 0.31 0.28 0.29 0.02 –
CAC3696 Hypothetical protein 0.43 0.31 0.30 0.29 0.33 0.07 S
CA_P0004 Cysteine protease 0.02 0.02 0.04 0.04 0.03 0.01 O
CA_P0009 Response regulator 0.25 0.28 0.51 0.24 0.32 0.13 T
CA_P0010 bgla Beta-glucosidase 0.30 0.32 0.35 0.33 0.32 0.02 G
CA_P0040 Xre family DNA-binding domain and TPR repeats containing protein 0.21 0.19 – 0.26 0.22 0.03 –
CA_P0044 Hypothetical protein 0.18 0.17 0.29 0.19 0.21 0.05 –
CA_P0045 Glycosyl transferase 0.19 0.18 0.23 0.14 0.18 0.04 G,C
CA_P0053 xynb Xylanase 0.06 0.07 0.05 0.05 0.06 0.01 G
CA_P0054 Xylanase/chitin deacetylase family protein 0.06 0.06 0.06 0.04 0.05 0.01 G
CA_P0056 pell Pectate lyase 0.10 0.09 0.16 0.11 0.12 0.03 –
CA_P0065 Secreted metalloprotease 0.07 0.07 0.07 0.06 0.06 0.004 –
CA_P0102 Membrane protein 0.11 0.10 0.12 0.08 0.10 0.02 R
CA_P0112 Hypothetical protein 0.27 0.25 0.18 0.17 0.22 0.05 –
CA_P0116 Xylanase 0.17 0.17 0.28 0.28 0.22 0.06 G
CA_P0117 Beta-xylosidase 0.12 0.12 0.22 0.19 0.17 0.05 –
CA_P0118 Xylan degradation enzyme 0.14 0.16 0.18 0.16 0.16 0.02 M
CA_P0119 Xylan degradation enzyme 0.09 0.09 0.15 0.12 0.11 0.03 M
CA_P0120 Xylan degradation enzyme 0.09 0.10 0.16 0.13 0.12 0.03 G
CA_P0128 Permease, MDR related 0.30 0.25 0.05 0.04 0.16 0.13 G
CA_P0129 Glycogen-binding regulatory subunit of S/T protein phosphatase I 0.19 0.21 0.22 0.25 0.22 0.02 –
CA_P0162 adhe1 Aldehyde dehydrogenase 0.012 0.009 0.008 0.004 0.008 0.003 C
CA_P0163 ctfa Butyrate-acetoacetate CoA-transferase subunit A 0.009 0.010 0.009 0.004 0.008 0.003 I
CA_P0164 ctfb Butyrate-acetoacetate CoA-transferase subunit B 0.014 0.010 0.007 0.004 0.008 0.004 I
CA_P0168 amyA Alpha-amylase 0.11 0.09 0.16 0.09 0.11 0.03 G

Genes are listed in order of ORFs and considered as significantly induced when the average fold regulation was ≤0.33 and the values in at least three out of four microarrays were ≤0.5

aProtein names according to Nölling et al. (2001)

bCluster of orthologous groups (Tatusov et al. 2000)