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. Author manuscript; available in PMC: 2011 Nov 30.
Published in final edited form as: J Nephrol. 2010 Nov-Dec;23(Suppl 16):S136–S144.

Fig. 1.

Fig. 1

Proposed model of how Klotho regulates NaPi-2a in the apical membrane of the renal proximal tubule. Klotho functions acutely as a direct extracellular enzyme deglycosylating NaPi-2a protein and/or a putative regulatory protein (black) to reduce transport activity (no. 1 in fgure). the deglycosylated NaPi-2a is sensitized to resident protease(s) in brush border membrane (BBM) and is proteolytically degraded (no. 2). Several hours later, deglycosylated NaPi-2a protein is endocytosed from BBM into the intracellular pool (no. 3).