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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Nat Genet. 2011 Oct 9;43(11):1114–1118. doi: 10.1038/ng.958

Figure 2.

Figure 2

Figure 2

Discovery sample association results at two novel melanoma susceptibility loci on chromosome 1 for both SNPs directly genotyped in all Australian samples and imputed SNPs. Genotyped SNPs are indicated by solid triangles and imputed SNPs by hollow circles. The top ranked SNP at each locus is shown as a solid purple diamond (this SNP is an imputed SNP at both loci). Imputation p-values for all SNPs are plotted. Note imputed and genotyped p-values for genotyped SNPs differ slightly because for the imputed result, analysis is based on dosage scores whereas with genotyped SNPs hard genotype calls are used. Association results shown are for (A) the chromosome 1 locus near 149 Mb, and (B) SNPs in the vicinity of the PARP1 association signal. The color scheme indicates linkage disequilibrium between the most strongly-associated SNPs for the 149 Mb and PARP1 region (shown in purple, rs267735 and rs2695238, respectively) and other genotyped SNPs in the two regions.