Table 1. IC50 values of the representative set of active compounds identified in the HTS.
Set 1 | ||
No. | Compound | IC50 1 (µM) |
1 | A6035 | 0.29±0.02 |
2 | A7966 | 0.38±0.02 |
3 | A9007 | 1.2±0.1 |
4 | A7686 | 1.4±0.1 |
5 | A5388 | 1.5±0.3 |
6 | A7528 | 1.8±0.1 |
7 | A5315 | 1.9±0.4 |
8 | A7372 | 1.9±0.7 |
9 | A7998 | 2.9±0.5 |
10 | A5846 | 3.1±0.9 |
11 | A6623 | 3.3±1.8 |
12 | A6164 | 3.5±0.9 |
13 | A7175 | 3.5±1.2 |
14 | A5918 | 3.6±0.8 |
15 | A9005 | 3.9±0.3 |
16 | A5130 | 5.3±0.3 |
17 | A5744 | 6.0±4.3 |
18 | A5922 | 6.2±0.8 |
19 | A5332 | 6.8±3.0 |
20 | A7988 | 7.1±0.6 |
21 | A6144 | 11.6±0.9 |
22 | A6386 | 13.3±2.2 |
23 | A6676 | 14.1±1.4 |
24 | A6659 | 25.7±5.0 |
25 | A5319 | 30.2±1.3 |
26 | A6435 | 40.8±16.5 |
27 | A5320 | 43.4±12.0 |
28 | A7124 | 47.6±27.6 |
29 | A6642 | 50.9±3.4 |
30 | A7695 | 81.8±23.9 |
Mean ± standard deviations of 2–4 determinations.