Table 2. IC50 values of the hits for which crystal structures were successfully determined.
Compound | IC50 1 (µM) |
C7653 | 0.20±0.05 |
C7643 | 0.54±0.03 |
C5685 | 1.3±0.1 |
C6905 | 2.0±0.1 |
C7491 | 21.4±1.7 |
C5231 | 36.0±6.3 |
Mean ± standard deviations of 2–5 determinations.