Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Nov 3;11:66. doi: 10.1186/1471-213X-11-66

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright ©2011 Davis et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Sequence alignments of three common EcR cofactors with their human homologs. A. Subsection of Twister protein sequence contains a highly conserved extended LXD domain (highlighted orange) and a region of what may be an evolving LXD domain (red box). B. Kismet also contains two completely conserved LXD motifs (highlighted yellow). C. Moira and its human homolog SMARCC2 which is part of the well know steroid receptor cofactor complex SWI/SNF show presence of both LXD and extended LXD motifs. Both genes have been shown to be involved in both activation and repression of developmental target genes.