Table 2. Immune and inflammatory blood markers at baseline, and during sleep restriction and recovery periods.

	Baseline	Restriction 1	Restriction 3	Restriction 5	Recovery 1	Recovery 2	Recovery 3	P Value
Leukocytes(103cells/μl)	6.77(5.58-7.32)	7.2(5.92-7.85)	6.86(6.47-7.43)	7.40(6.30-8.22)	7.10(5.95-7.76)	6.50(6.07-8.30)	6.70(5.97-7.90)	0.36
Neutrophils(103cells/μl)	3.56(2.66-4.13)	3.76(2.96-4.63)	3.72(3.34-4.02)	3.96(3.28-4.34)	3.58(3.21-4.05)	3.79(2.70-4.57)	3.42(2.97-4.45)	0.19
Lymphocytes(103cells/μl)	2.42(2.27-2.64)	2.35(1.93-2.59)	2.34(2.1-2.5)	2.44(2.0-2.6)	2.56(2.3-2.7)	2.37(2.1-4.1)	3.3(2.6-4.1)	0.62
Monocytes(103cells/μl)	0.55(0.49-0.62)	0.61(0.53-0.72)	0.56(0.51-0.68)	0.61(0.51-0.72)	0.57(0.52-0.66)	0.65(0.49-0.74)	0.65(0.50-0.71)	0.18
Fibrinogen(mg/dl)	2.76(2.49-2.98)	2.95(2.71-3.07)	2.78(2.54-2.98)	2.71(2.41-2.94)	2.72(2.39-2.99)	2.74(2.47-2.95)	2.90(2.44-3.18)	0.13
Hs-CRP(mg/dl)	0.09(0.07-0.11)	0.10(0.06-0.14)	0.08(0.06-0.09)	0.08(0.05-0.09)	0.08(0.06-0.09)	0.06(0.06-0.09)	0.07(0.05-0.11)	0.11
Interleukin-8(pg/ml)	4.70(4.34-6.00)	6.36(4.33-6.00)	4.78(3.39-5.86)	4.68(4.03-6.91)	5.88(4.59-9.61)	6.60(3.75-10.457)	4.36(3.61-5.48)	0.11
ApoB (mg/dl)	74.1(71.7-89.4)	72.9(68.1-93.7)	71.6(64.4-93.2)	68.5(64.0-85.6)	68.9(64.5-85.9)	73.1(63.0-86.7)	66.1*(64.0-84.9)	0.007
Mox-LDL(µg/ml)	8.1(3.35-11.50)	12.3*(4.51-28.19)	14.6*(4.47-23.03)	10.3(4.40-11.92)	9.2(3.51-12.73)	8.8(3.47-14.19)	6.8(4.87-11.11)	0.002
IGF-1(pg/ml)	0.95(0.72-1.09)	0.88(0.69-1.23)	0.97(0.66-1.40)	0.95(0.76-1.22)	1.18*(0.83-1.38)	0.92(0.80-1.16)	0.87(0.80-1.08)	0.03

Values are shown as medians (25%–75% range). Baseline (average of the 3 baseline days for each volunteer) was used as control and other days as the comparative groups. Data comparisons with the baseline were performed using a Friedman Repeated Measures Analysis of Variance on Ranks and a Dunn's post-hoc test.

*Significant difference vs. baseline (P<0.05).