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. 2011 Nov 30;6(11):e28223. doi: 10.1371/journal.pone.0028223

Figure 1. Overview of DNA methylation patterns in relation to gene expression.

Figure 1

A. Genome wide DNA methylation, mRNA, and miRNA profiles from bladder cancer tissues and matched normal adjacent tissues. The log2-transformed average fold changes (tumor/normal) for methylation status (red), mRNA expression level (green), and miRNA expression level (blue) from all patients were drawn across the whole genome. The y-axis represents the log2 ratio, and the dashed lines represent the significance threshold (|log2Ratio| = 1). B. Distribution of the methylation levels in different types of genic regions between bladder cancer tissues and matched normal adjacent tissues. The box-plots for the distribution of DNA methylation levels based on the log2-transformed tag fold change (tumor/normal) from MMSDK across all patients were drawn. Types include CpG-rich promoters, CpG-poor promoters, exons, and introns.