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. 2011 Nov 30;6(11):e28186. doi: 10.1371/journal.pone.0028186

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Park et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Δ6- and Δ8-desaturation steps are absent in MCF7, leading to Δ5-desaturation of 11,14–20∶2 to 5,11,14–20∶3 when FADS1 is functional. The analogous pathways for n–3 LCPUFA convert 11,14,17–20∶3→5,11,14,17–20∶4 (not shown). FADS2 is also believed to be involved in C22 LCPUFA biosynthesis (not shown).