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. 2011 Nov 30;6(11):e28376. doi: 10.1371/journal.pone.0028376

Figure 2. Effects of mifepristone and the Porsolt test on the survival of 1 week-old cells.

Figure 2

A Mifepristone prevented the decrease in the number of 1 week-old IdU+ cells induced by exposure to the Porsolt test (interaction p = 0.005). B-I Immunohistochemistry against IdU (red) in cells counterstained with DAPI (blue). Representative images of 1 week-old cells from each of the four experimental groups (B–E), and magnifications (F–I). Mifepristone blocked the decrease in cell survival provoked by the Porsolt test (E, I) but it had no effect on control, unstressed animals (D, H). J Exposure to the Porsolt test increased the percentage of 1 week-old IdU+ cells that were also fractin+ (p = 0.02), an effect that was blocked by mifepristone treatment (interaction p = 0.02). ML: Molecular layer; GCL: Granule cell layer; SGZ: Subgranular zone; H: Hilus. Scale bar = 100 µm.