Table 2. Mean Number of Minor Alleles from 31 Folate Pathway Genes in Cases vs. Controls for Different Variant Subsets.
| Variant Subset | All Cases | All Controls | Permuted P-Value | Hispanic Cases | Hispanic Controls | Permuted P-value | White Cases | White Controls | Permuted P-value |
| COMMON a | |||||||||
| All | 116.8±13.2 | 119.1±15.3 | 0.1 | 115.3±12.9 | 117.7±14.1 | 0.12 | 125.7±10.8 | 125.5±15.4 | 0.95 |
| Nonsynonymous | 11±2.8 | 11.3±3 | 0.2 | 11±2.6 | 11.5±3 | 0.12 | 12.2±3.2 | 12.5±2.9 | 0.65 |
| Non-Coding | 91.2±11 | 93.4±13.2 | 0.06 | 90.1±10.5 | 92.3±12.1 | 0.13 | 95.8±10.2 | 97±12.9 | 0.62 |
| RARE a | |||||||||
| All | 7.8 (1–54) | 7.8 (0–42) | 0.54 | 6.1 (0–20) | 6.1 (0–22) | 0.82 | 5 (0–34) | 4.4 (0–13) | 0.73 |
| Nonsynonymous | 1 (0–9) | 1 (0–6) | 0.96 | 0.9 (0–5) | 0.9 (0–5) | 0.93 | 0.7 (0–4) | 0.5 (0–2) | 0.6 |
| Non-Coding | 6.2 (0–43) | 6.2 (0–38) | 0.47 | 4.7 (0–18) | 4.7 (0–19) | 0.81 | 3.8 (0–29) | 3.5 (0–11) | 0.48 |
a
Common alleles are defined as MAF≥2.5% within the specific race-ethnic group analyzed, whereas rare alleles are MAF<2.5%. Means are shown±standard deviation for common variant analyses where the distributions were near normal. For rare variants, the distributions were tailed (see Figure 1B) and the range of values is provided in parentheses. Permuted P-values were calculated as in Materials and Methods, and were not adjusted for multiple comparisons.