Figure 4.

Candidate of cruciform-mediated ultramicro inversions. (A) Nucleotide alignments of human chromosome (chromosome 4: 39332472-39332603) and its orthologous sequences to the chimpanzee and gorilla genomes including the ultramicro inversions sandwiched by inverse repeats. Characters in bold-blue and green represent ultramicro inversions and inverted repeats, respectively. The inverted repeat at the 3' end of ultramicro inversions may have been inserted by cruciform-formation following inversion. (B) One strand of cruciform-DNA inferred by the Mfold program [25]. Characters highlighted in blue and green represent the ultramicro inversion and inverted repeats, respectively.