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. 2011 Sep 30;12:478. doi: 10.1186/1471-2164-12-478

Table 3.

IC50 values for CpCDPK1 inhibitors tested.

Compound IC50 (nM)
Inline graphic 1.3 ± 0.2
Inline graphic 2.1 ± 0.2
Inline graphic 2.1 ± 0.3
Inline graphic 2.8 ± 0.2
Inline graphic 3.4 ± 0.1
Inline graphic 3.4 ± 0.1
Inline graphic 0.9 ± 0.1
Inline graphic 2.6 ± 0.1
Inline graphic 4.7 ± 0.4
Inline graphic 7 ± 0.2
Inline graphic 5.6 ± 0.5
Inline graphic 15.2 ± 4.4
Inline graphic 5.6 ± 0.8
Inline graphic 7.7 ± 1
Inline graphic 22 ± 2
Inline graphic 249 ± 73
Inline graphic 96 ± 13
Inline graphic 88 ± 0.14
Inline graphic 616 ± 203
Inline graphic 2722 ± 72

All compounds were tested using 500 μM ATP and 500 μM Syntide2 as described in Methods. A concentration range from 1 nM to 1 μM for all compounds was used except for CZ25, CZ15 and 1nA-PP1 (2 nM to 2 μM), CZ27 (4 nM to 4 μM) and JC022 (8 nM to 8 μM).