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MT-IIA promotes neurite outgrowth through a megalin- and MAPK-dependent pathway. Dissociated DRG neurons were treated with RAP or PD98059 30 min prior to treatment with MT. Quantification of neurite length 24 h after MT treatment found that both RAP and PD98059 blocked the neuritogenic effect of MT-IIA. (*p < 0.05 compared to other treatment group; n = 20–30 per treatment group; error bars = standard errors of mean fold changes)
