Fig. 5.

Summary of the differential cellular and plaque labeling by various antibodies targeting at different epitopes on β-amyloid precursor protein (APP) and its amyloidogenic proteolytic products. All Aβ antibodies label extracellular plaques. 22C11, CT15, 6E10 and 4G8 label neuronal somata and proximal dendrites. Dystrophic axons can be labeled by 22C11 and CT15, and by antibodies to Aβ N-terminal and mid-region, but not by Ter40 and Ter42. The perisomatic terminals are detected by CT15 but not 22C11, and by antibodies to Aβ N-terminal and mid-region but not Aβ C-terminal. Note that the perisomatic terminals and dystrophic axons also exhibit increased BACE1 labeling.