Table 1.
Biodistribution of 64Cu-DOTA-anti-ALCAM CysDb at 21 h in female nude mice bearing ALCAM-positive (HPAF-II or BxPC-3) and ALCAM-negative (C6) tumors and at 4 h in non-tumor-bearing female Alcam−/− mice.
| Tissue | % ID/g (mean ± SD) | ||
|---|---|---|---|
| HPAF-II (n = 5) | BxPC-3 (n = 4) | Alcam−/− (n = 2) | |
| 21 h | 21 h | 4 h | |
| Positive tumor (T) | 1.8 ± 0.5 | 2.5 ± 0.5 | |
| Negative tumor (C6) | 1.0 ± 0.1 | 1.0 ± 0.1 | |
| Liver | 6.6 ± 0.5 | 6.8 ± 1.4 | 5.4 ± 0.1 |
| Spleen | 1.7 ± 0.2 | 1.8 ± 0.3 | 2.2 ± 0.7 |
| Kidneys | 42 ± 5.0 | 40 ± 0.8 | 90 ± 3.5 |
| Lung | 1.8 ± 0.5 | 2.3 ± 0.3 | 2.1 ± 0.3 |
| Blood | 0.7 ± 0.1 | 0.9 ± 0.1 | 1.0 ± 0.3 |
| Carcass | 0.8 ± <0.1 | 1.0 ± 0.1 | 1.4 ± 0.2 |
| Ratios | |||
| T/blood | 2.5 ± 0.9 | 2.9 ± 0.6 | |
| T/C6 | 1.9 ± 0.6 | 2.4 ± 0.6 | |