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. Author manuscript; available in PMC: 2012 Nov 23.
Published in final edited form as: Cell. 2011 Nov 23;147(5):1066–1079. doi: 10.1016/j.cell.2011.10.039

Figure 7. Lin28A and Lin28B expression in primary human cancers.

Figure 7

(A) q.RT-PCR analysis of Lin28A, Lin28B and let-7a expression levels in normal and colon cancer tissues. Tumor samples were further classified into two groups expressing either high Lin28A or Lin28B. Data expressed as mean ± SE. n=3. (B) Immunohistochemistry for Lin28A, Lin28B and in situ hybridization for let-7a and U6 in normal colon tissues and colon adenocarcinomas. See also Figure S4. (C) q.RT-PCR analysis of Lin28A, Lin28B and let-7a in human normal and breast cancer tissues. Tumor samples were further classified into two groups expressing either high Lin28A or Lin28B. Data expressed as mean ±SE. n=3. (D) Lin28A, Lin28B and let-7a expression levels in different breast cancer subtypes. (E) Correlation between Lin28A and Lin28B mRNA levels assessed by q.RT-PCR with NF-κB phosphorylation status assessed by ELISA assay. (E) Heatmap representation of Lin28A and Lin28B in carcinomas of different origin measured by q.RT-PCR.