Overall survival according to independent prognostic factors in learning sample (A–C) and validation sample (D–F). (A): WHO PS (learning sample), (B): serum LDH level (learning sample), (C): number of metastatic sites (learning sample), (D): WHO PS (validation sample), (E): serum LDH level (validation sample), and (F): number of metastatic sites (validation sample). Abbreviations: LDH, lactate dehydrogenase; PS, performance status; WHO, World Health Organization.