Table 1. Monoamine Uptake Inhibition (IC50 nM).
Compound | [3H]DA | [3H]5HT | Ratio 5HT/DA |
---|---|---|---|
Cocainea | 310 | 260 | 0.8 |
RTI-112a | 1.1 | 1.4 | 1.3 |
RTI-113a | 3.0 | 229 | 76 |
RTI-177a | 1.9 | 235 | 124 |
RTI-336b | 12 | 522 | 44 |
GBR12909c | 1.0 | 170 | 170 |
Data from Kuhar et al. (1999). Uptake values were determined using rat tissue.
Values supplied by NIDA under the Cocaine Treatment Discovery Program (CTDP) . Uptake values were determined using cloned hDAT and hSERT.
Data from Anderson (1989). Uptake values were determined using rat tissue.