Table 4.
25-Hydroxyvitamin D (25[OH]D) Status and Prevalent (OR (95% CI)) and Incident (HR (95% CI)) Mobility and ADL Disability: CHS All Stars
| 25(OH)D | |||
|---|---|---|---|
| <20 ng/mL | 20–<30 ng/mL | ≥30 ng/mL | |
| Prevalent disability | |||
| Mobility disability | |||
| N | 303 | 355 | 329 |
| Prevalent disability, N (%) | 111 (36.6) | 117 (33.0) | 79 (24.0) |
| OR (95% CI): Model 1 | 1.85 (1.28–2.66) | 1.66 (1.17–2.34) | 1.00 |
| OR (95% CI): Model 2 | 1.44 (0.96–2.14) | 1.53 (1.05–2.22) | 1.00 |
| ADL disability | |||
| N | 304 | 355 | 329 |
| Prevalent disability, N (%) | 106 (34.9) | 109 (30.7) | 78 (23.7) |
| OR (95% CI): Model 1 | 1.81 (1.26–2.61) | 1.50 (1.06–2.12) | 1.00 |
| OR (95% CI): Model 2 | 1.51 (1.01–2.25) | 1.37 (0.94–2.00) | 1.00 |
| Incident disability* | |||
| Mobility disability | |||
| N | 183 | 227 | 243 |
| Disability events, N (%) | 81 (44.3) | 54 (23.8) | 61 (25.1) |
| HR (95% CI): Model 1 | 1.82 (1.27–2.60) | 0.90 (0.63–1.31) | 1.00 |
| HR (95% CI): Model 2 | 1.56 (1.06–2.30) | 0.83 (0.56–1.21) | 1.00 |
| ADL disability | |||
| N | 188 | 234 | 243 |
| Disability events, N (%) | 44 (23.4) | 37 (15.8) | 45 (18.5) |
| HR (95% CI): Model 1 | 1.18 (0.75–1.84) | 0.79 (0.51–1.22) | 1.00 |
| HR (95% CI): Model 2 | 0.98 (0.61–1.56) | 0.75 (0.48–1.18) | 1.00 |
Model 1 adjusted for age, gender, race, education, field center, and season.
Model 2 adjusted for variables in model 1 plus BMI status, walking for physical activity, smoking, alcohol use, creatinine, depression, cognition, diabetes, osteoporosis, and cardiovascular disease.
*
Among participants free of mobility or ADL disability at baseline with at least two follow-up contacts over 3 years.